MC13-0081 Cell cycle regulatory proteins in pancreatic cancer
نویسندگان
چکیده
منابع مشابه
Disruption of Cell Cycle Machinery in Pancreatic Cancer
This chapter discusses the role of cell cycle machinery in initiation and progression of pancreatic cancer. Normal pancreatic cells—their types, organization, and functions—are first described to characterize the environment in which cellular transformation and tumor expansion occurs. The epidemiology and histology of pancreatic cancer is then briefly presented to emphasize the urgent need for ...
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The cell cycle is the cascade of events that allows a growing cell to duplicate all its components and split into two daughter cells. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors grouped into two families: the INK4 inhibitors (p16, p15, ...
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Markers of cellular proliferation have proven to be useful prognostic markers in several tumor types. Recently, immunoreactivity for cyclins was found to provide an independent marker of tumor proliferation in breast cancer. In this study, we sought to determine the pattern of immunoreactivity for cyclins A, B, E, and Ki-67 in surgically resected prostate cancer and to determine their possible ...
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BACKGROUND AND OBJECTIVES The pathogeny of B-cell chronic lymphocytic leukemia (B-CLL) involves both deregulated proliferation and inhibition of cell death. A particular role in the regulation of these phenomena is played by proteins involved in early G1 phase regulation: pRb kinases: cyclin-dependent kinases (cdk): cdk4 and cdk6 activated by cyclins D, and universal cdk inhibitor p27(Kip1). ...
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ژورنال
عنوان ژورنال: European Journal of Cancer
سال: 2013
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(13)70186-2